RM4330

Glutamine Synthetase (14W15) Rabbit Monoclonal Antibody

GLNA; GS; GLUL; GLNS; PIG43 ; PIG59; Glutamine synthetase;

Affinity-chromatography

常规抗体

GLUL {ECO:0000303|PubMed:30158707, ECO:0000312|HGNC:HGNC:4341}

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

2752

P15104

A synthetic peptide of human Glutamine Synthetase

WB: 1:1000-1:5000 IHC: 1:200-1:500

42kDa

42kDa

Rabbit IgG

Glutamine Synthetase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in endothelial cells.

Cytoplasm, cytosol. Microsome {ECO:0000250|UniProtKB:P09606}. Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane; Lipid-anchor. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane

Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351).

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