产品名称
Thrombomodulin (14C15) Rabbit Monoclonal Antibody
别名
CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P07204
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50
注意事项
Thrombomodulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Endothelial cells are unique in synthesizing thrombomodulin
细胞定位
Membrane; Single-pass type I membrane protein.
功能
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
