产品名称
TTF1 (3X12) Rabbit Monoclonal Antibody
别名
BCH; BHC; NK-2; TEBP; TTF1; NKX2A; TITF1; TTF-1; NKX2.1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P43699
免疫原
A synthetic peptide of human TTF1
稀释度
WB: 1:1000 IHC: 1:50 ICC/IF: 1:20-1:50 FC: 1:20
注意事项
TTF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Nucleus {ECO:0000250|UniProtKB:P50220}.
功能
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).
