产品名称
ErbB3 (HER3) (15E6) Rabbit Monoclonal Antibody
别名
ERB3, ERBB3, HER3, c-erbB3, kinase ErbB3
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P21860
免疫原
A synthetic peptide of human ErbB 3
稀释度
WB: 1:1000 IHC: 1:50 FC: 1:20
注意事项
ErbB3 (HER3) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Epithelial tissues and brain.
细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein
功能
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:
20682778). May also be activated by CSPG5 (PubMed:
15358134). Involved in the regulation of myeloid cell differentiation (PubMed:
27416908).
