RM4255

CD86 (2V8) Rabbit Monoclonal Antibody

CD86;B7-2;B70;CD28LG2;LAB72;MGC34413; CTLA4 counter receptor B72; CLS1; Ly58; MB7;

Affinity-chromatography

常规抗体

CD86

CD28LG2

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

942

P42081

Recombinant protein of human CD86

WB: 1:1000 ICC/IF: 1:100 FC: 1:100 IP: 1:20

60-85kDa

38kDa

Rabbit IgG

CD86 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed by activated B-lymphocytes and monocytes.

Cell membrane; Single-pass type I membrane protein

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).

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