RM4253

MMP14 (19L14) Rabbit Monoclonal Antibody

MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1;

Affinity-chromatography

常规抗体

MMP14

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

4323

P50281

A synthetic peptide of human MMP14

WB: 1:1000 IHC: 1:50-1:100 ICC/IF: 1:200-1:1000 FC: 1:100-1:200 IP: 1:20

66kDa

66kDa

Rabbit IgG

MMP14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV Forms a complex with BST2 and localizes to the cytoplasm

Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).

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