RM4232

LRP1 (3Z8) Rabbit Monoclonal Antibody

A2MR; alpha 2MR; Alpha 2 macroglobulin receptor; CD91; APR; LRP1; LRP85; TGFBR5;

Affinity-chromatography

常规抗体

LRP1

A2MR, APR

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

4035

Q07954

A synthetic peptide of human LRP1

WB: 1:2000-1:20000 IHC: 1:50 ICC/IF: 1:100 FC: 1:100 IP: 1:20

85kDa

85kDa

Rabbit IgG

LRP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Most abundant in liver, brain and lung.

[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein Membrane, coated pit [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2- macroglobulin receptor (PubMed:26142438, PubMed:1702392). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553).

现货