产品名称
S100B (6D3) Rabbit Monoclonal Antibody
别名
S100B;NEF;S100;S100beta ;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P04271
免疫原
A synthetic peptide of human S100B
稀释度
WB: 1:1000 IHC: 1:200 ICC/IF: 1:100 IP: 1:50
注意事项
S100B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues
功能
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
