RM4220

MCM2 (1K1) Rabbit Monoclonal Antibody

BM28; CCNL1; cdc19; CDCL1; cell devision cycle-like 1; cyclin-like 1; D3S3194; MCM2; MCM2 minichromosome maintenance deficient 2, mitotin;

Affinity-chromatography

常规抗体

MCM2

BM28, CCNL1, CDCL1, KIAA0030

WB

Human,Mouse,Rat

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

4171

P49736

A synthetic peptide of human MCM2

WB: 1:1000 IHC: 1:50 ICC/IF: 1:200 FC: 1:20

125kDa

102kDa

Rabbit IgG

MCM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Nucleus. Chromosome {ECO:0000250|UniProtKB:P55861}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P55861}

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.

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