Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking (PubMed:
20949042, PubMed:
22012985, PubMed:
26824392, PubMed:
29125462, PubMed:
28720718, PubMed:
29127255, PubMed:
30398148, PubMed:
29212815, PubMed:
30635421, PubMed:
21850687, PubMed:
23395371, PubMed:
17114044, PubMed:
24687852, PubMed:
26014385, PubMed:
25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:
26824392, PubMed:
28720718, PubMed:
29127255, PubMed:
30398148, PubMed:
29212815, PubMed:
29125462, PubMed:
30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:
26824392, PubMed:
28720718, PubMed:
29127255, PubMed:
30398148, PubMed:
29212815, PubMed:
29125462, PubMed:
30635421, PubMed:
23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:
26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr- 72' on RAB8A (PubMed:
26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:
29125462, PubMed:
30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:
23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:
17114044). Plays a role in synaptic vesicle trafficking (PubMed:
24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:
25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:
22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:
22012985). Phosphorylates PRDX3 (PubMed:
21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:
28720718). Independent of its kinase activity, inhibits the proteosomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:
26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:
18230735, PubMed:
26824392, PubMed:
29125462, PubMed:
28720718, PubMed:
29212815).
