产品名称
C9 (12U11) Rabbit Monoclonal Antibody
别名
Complement component C9; Comple Complement component C9bment component C9a;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P02748
注意事项
C9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Plasma (at protein level).
细胞定位
Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble monomer Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore
功能
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:
9634479, PubMed:
9212048, PubMed:
26841934). C9 is the pore-forming subunit of the MAC (PubMed:
4055801, PubMed:
26841934, PubMed:
30111885).
