产品名称
TACC3 (9J4) Rabbit Monoclonal Antibody
别名
ERIC-1; ERIC1; TAC3; Transforming acidic coiled-coil-containing protein 3;TACC3;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
Q9Y6A5
免疫原
A synthetic peptide of human TACC3
稀释度
WB: 1:1000 IHC: 1:100 ICC/IF: 1:200-1:500
注意事项
TACC3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9PTG8}. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
功能
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:
21297582, PubMed:
23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:
14767476).
