RM4157

Alpha Synuclein (18R1) Rabbit Monoclonal Antibody

Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; PARK1; PARK4; PD1; SNCA;

Affinity-chromatography

常规抗体

SNCA

NACP, PARK1

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

6622

P37840

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

14kDa

Rabbit IgG

Alpha Synuclein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain

Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted Note=Membrane-bound in dopaminergic neurons

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).

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