RM4144

CD46 (12M15) Rabbit Monoclonal Antibody

MCP; MIC10; TLX; TRA2.10; CD46;

Affinity-chromatography

常规抗体

CD46

MCP, MIC10

WB

Human

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

4179

P15529

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

44kDa

Rabbit IgG

CD46 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed by all cells except erythrocytes.

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

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