产品名称
Olig2 (15Z2) Rabbit Monoclonal Antibody
别名
Oligo2; bHLHb1; Class E basic helix-loop-helix protein 19; bHLHe19; OLIG2; BHLHB1; BHLHE19; PRKC;
纯度
Affinity-chromatography
蛋白名称
BHLHB1, BHLHE19, PRKCBP2, RACK17
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q13516
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
Olig2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
功能
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
