产品名称
Rab4A (17S4) Rabbit Monoclonal Antibody
别名
Rab4; RAB4A; HRES 1; RAB4; Ras related protein Rab 4A;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P20338
稀释度
WB 1:1000~1:2000 ICC/IF 1:50~1:200 IP 1:50
注意事项
Rab4A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Membrane; Peripheral membrane protein. Cytoplasm Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1
功能
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (PubMed:
15907487, PubMed:
16034420). Involved in protein transport (PubMed:
29425100). Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:
29425100). Acts as a regulator of platelet alpha- granule release during activation and aggregation of platelets (By similarity).
