产品名称
PTBP2 (17R13) Rabbit Monoclonal Antibody
别名
brPTB; MIBP; nPTB; Polypyrimidine tract binding protein 2; PTB like protein; PTBP 2Ptbp2; Splicing regulator;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
Q9UKA9
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
注意事项
PTBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues
细胞定位
Nucleus {ECO:0000250|UniProtKB:Q91Z31}.
功能
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation.
