产品名称
HESX1 Rabbit Polyclonal Antibody
蛋白名称
Homeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UBX0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBX0/entry
Mouse Swissprot No.
Q61658
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61658
免疫原
Synthesized peptide derived from part region of human protein
特异性
HESX1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008],
组织表达
Fibrosarcoma,Teratocarcinoma,
功能
developmental stage:Strongly expressed in Rathke pouch in seven-week-old embryo.,disease:Defects in HESX1 are a cause of septooptic dysplasia (SOD) [MIM:182230]; also known as de Morsier syndrome. SOD is a rare autosomal recessive disease. SOD is characterized by optic nerve hypoplasia, absence of the corpus callosum and hypoplasia of the pituitary gland with panhypopopituitarism.,disease:Defects in HESX1 are associated with pituitary dwarfism III [MIM:262600]; also known as combined pituitary hormone deficiency (CPHD). This syndrome is manifested by deficiencies in anterior pituitary tropic hormones.,function:Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation.,similarity:Belongs to the ANF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Can form heterodimers with PROP1 in binding to DNA (By similarity). Interacts with TLE1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
