产品名称
Phospho-LAT (Y220) (2B4) Rabbit Monoclonal Antibody
别名
36 kDa phospho-tyrosine adaptor protein; LAT1; lat; pp36
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
O43561
免疫原
A synthetic phosphopeptide corresponding to residues surrounding
Tyr200 of human LAT
稀释度
WB: 1:2000 ICC/IF: 1:50
注意事项
Phospho-LAT (Y220) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
细胞定位
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts
功能
Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
