RM4085

pro Caspase 3 (2N2) Rabbit Monoclonal Antibody

CASP3; Caspase-3; APOPAIN; CPP32; CPP32B; SCA-1;

Affinity-chromatography

常规抗体

CASP3

CPP32

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

836

P42574

A synthetic peptide of human pro Caspase 3

WB: 1:1000 IHC: 1:200-1:500 ICC/IF: 1:200 FC: 1:100 IP: 1:20

32kDa

32kDa

Rabbit IgG

pro Caspase 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system

Cytoplasm.

Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216- Asp-|-Gly-217' bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix- loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486).

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