RM4069

Bcl-2 (10F16) Rabbit Monoclonal Antibody

Apoptosis regulator Bcl-2; BCL2;

Affinity-chromatography

常规抗体

BCL2

WB

Human,Mouse

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

596

P10415

Recombinant protein of human Bcl-2

WB: 1:1000 IHC: 1:200-1:500 FC: 1:200

26kDa

26kDa

Rabbit IgG

Bcl-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Expressed in a variety of tissues.

Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:21358617, PubMed:20889974). May attenuate inflammation by impairing NLRP1- inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

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