产品名称
IKB alpha (6B2) Rabbit Monoclonal Antibody
别名
I-kappa-B-alpha; NFKBI; NFKBIA; NF-kappaB inhibitor alpha; IKBA; IkappaBalpha; MAD3; RL/IF-1;
纯度
Affinity-chromatography
存储缓冲液
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
Human Swissprot No.
P25963
免疫原
A synthetic peptide of human IKB alpha
稀释度
WB: 1:2000 IHC: 1:20-1:500 ICC/IF: 1:100 FC: 1:100
注意事项
IKB alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
细胞定位
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
功能
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
