产品名称
DMA Rabbit Polyclonal Antibody
蛋白名称
HLA class II histocompatibility antigen, DM alpha chain (MHC class II antigen DMA) (Really interesting new gene 6 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P28067
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P28067/entry
Mouse Swissprot No.
P28078
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P28078
免疫原
Synthesized peptide derived from part region of human protein
特异性
DMA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008],
组织表达
Lung,Salivary gland,Skeletal muscle,
细胞定位
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Localizes to late endocytic compartment. Associates with lysosome membranes.
信号通路
Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;Viral myo
功能
function:Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.,polymorphism:The following alleles of DMA are known: DMA*0101, DMA*0102, DMA*0103 (DMA3.2) and DMA*0104 (DMA3.4). The sequence shown is that of DMA*0101.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subcellular location:Localizes to late endocytic compartment. Associates with lysosome membranes.,subunit:Heterodimer of an alpha chain (DMA) and a beta chain (DMB).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
