产品名称
Topoisomerase II alpha (2J12) Rabbit Monoclonal Antibody
别名
DNA topoisomerase II; DNA topoisomerase II-alpha; TOP2; TOP2A; TP2A; alpha isozyme;
纯度
Affinity-chromatography
存储缓冲液
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Human Swissprot No.
P11388
稀释度
WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50
注意事项
Topoisomerase II alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
组织表达
Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056)
细胞定位
Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus
功能
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:
17567603, PubMed:
18790802, PubMed:
22013166, PubMed:
22323612). May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
