RM4034

E Cadherin (12V6) Rabbit Monoclonal Antibody

Arc1;Cadherin 1;CAM 120/80;CD324;CDHE;E-Cad/CTF3;ECAD;Epithelial cadherin ;LCAM;Uvomorulin;CDH1;

Affinity-chromatography

常规抗体

CDH1

CDHE, UVO

WB

Human

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.

999

P12830

A synthetic peptide of human E Cadherin

WB: 1:5000 IHC: 1:500 ICC/IF: 1:500 FC: 1:100 IP: 1:50

80-120kDa(cleavages),135kDa

98kDa

Rabbit IgG

E Cadherin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Non-neural epithelial tissues.

Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane

Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

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