产品名称
GUC2B Rabbit Polyclonal Antibody
蛋白名称
Guanylate cyclase activator 2B [Cleaved into: Guanylate cyclase C-activating peptide 2 (Guanylate cyclase C-activating peptide II) (GCAP-II); Uroguanylin (UGN)]
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q16661
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16661/entry
Mouse Swissprot No.
O09051
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O09051
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P70668
免疫原
Synthesized peptide derived from part region of human protein AA range: 1-50
特异性
GUC2B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015],
组织表达
Stomach and intestine.
功能
function:Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.,similarity:Belongs to the guanylin family.,tissue specificity:Stomach and intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
