产品名称
GNL3 Rabbit Polyclonal Antibody
蛋白名称
Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BVP2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BVP2/entry
Mouse Swissprot No.
Q8CI11
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CI11
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q811S9
免疫原
Synthesized peptide derived from part region of human protein
特异性
GNL3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
组织表达
Increased levels in lung tissue in cancer patients.
细胞定位
Nucleus . Nucleus, nucleolus . Shuttles between the nucleus and nucleolus. .
功能
domain:In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.,domain:The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis.,function:May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.,similarity:Belongs to the MMR1/HSR1 GTP-binding protein family.,subcellular location:Shuttles between the nucleus and nucleolus.,subunit:May interact with p53/TP53 via its basic domain.,tissue specificity:Increased levels in lung tissue in cancer patients.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
