产品名称
GBB1 Rabbit Polyclonal Antibody
蛋白名称
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P62873
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P62873/entry
Mouse Swissprot No.
P62874
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62874
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P54311
免疫原
Synthesized peptide derived from part region of human protein
特异性
GBB1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
B-cell lymphoma,Brain,Fetal brain cortex,Liver,Melanoma,Muscle,Ovarian carcinoma,PC
细胞定位
photoreceptor inner segment,intracellular,lysosomal membrane,cytosol,heterotrimeric G-protein complex,plasma membrane,membrane,dendrite,photoreceptor outer segment membrane,myelin sheath,cell body,extracellular exosome,
信号通路
Chemokine;Taste transduction;
功能
function:Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.,similarity:Belongs to the WD repeat G protein beta family.,similarity:Contains 7 WD repeats.,subunit:G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
