产品名称
GNA11 Rabbit Polyclonal Antibody
蛋白名称
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P29992
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P29992/entry
Mouse Swissprot No.
P21278
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P21278
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9JID2
免疫原
Synthesized peptide derived from part region of human protein
特异性
GNA11 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013],
组织表达
Expressed in testis.
细胞定位
Cell membrane ; Lipid-anchor . Cytoplasm . In testicular cells, expressed exclusively in the cytoplasm.
信号通路
Calcium;Vascular smooth muscle contraction;Gap junction;Long-term depression;GnRH;
功能
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.,similarity:Belongs to the G-alpha family. G(q) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
