产品名称
AMRP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4043
Human Swissprot No.
P30533
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30533/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16976
Mouse Swissprot No.
P55302
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P55302
Rat Gene Link
https://www.uniprot.org/uniprot/116565
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99068
免疫原
Synthesized peptide derived from human AMRP AA range: 277-327
特异性
This antibody detects endogenous levels of AMRP at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
细胞定位
Rough endoplasmic reticulum lumen . Endoplasmic reticulum-Golgi intermediate compartment lumen . Golgi apparatus, cis-Golgi network . Golgi apparatus lumen . Endosome lumen . Cell surface . May be associated with receptors at the cell surface. .
功能
disease:In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.,function:Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.,PTM:N-glycosylated.,similarity:Belongs to the alpha-2-MRAP family.,subcellular location:Intracellular and associated with cell surface receptors. Found in the endoplasmic reticulum.,subunit:Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
