产品名称
GAS2 Rabbit Polyclonal Antibody
蛋白名称
Growth arrest-specific protein 2 (GAS-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43903
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43903/entry
Mouse Swissprot No.
P11862
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P11862
免疫原
Synthesized peptide derived from part region of human protein
特异性
GAS2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009],
组织表达
Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
细胞定位
Cytoplasm, cytoskeleton, stress fiber . Membrane ; Peripheral membrane protein . Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles. .
功能
developmental stage:Specifically expressed at growth arrest.,function:May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.,PTM:Cleaved, during apoptosis, on a specific aspartic residue by caspases.,PTM:Phosphorylated on serine residues during the G0-G1 transition phase.,similarity:Belongs to the GAS2 family.,similarity:Contains 1 CH (calponin-homology) domain.,subcellular location:Component of the microfilament system. Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts. Mainly membrane-associated. When hyperphosphorylated, accumulates at membrane ruffles.,tissue specificity:Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
