产品名称
GEM Rabbit Polyclonal Antibody
蛋白名称
GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P55040
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P55040/entry
Mouse Swissprot No.
P55041
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55041
免疫原
Synthesized peptide derived from part region of human protein
特异性
GEM Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
组织表达
Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.
细胞定位
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
功能
function:Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,induction:By mitogens.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the small GTPase superfamily. RGK family.,subunit:Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.,tissue specificity:Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
