产品名称
TRI23 Rabbit Polyclonal Antibody
基因名称
TRIM23 ARD1 ARFD1 RNF46
蛋白名称
E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P36406
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P36406/entry
Mouse Swissprot No.
Q8BGX0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BGX0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P36407
免疫原
Synthesized peptide derived from part region of human protein
特异性
TRI23 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Endomembrane system . Golgi apparatus membrane . Lysosome membrane . Membrane-associated with the Golgi complex and lysosomal structures.
功能
function:Not known, the C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:In the C-terminal section; belongs to the small GTPase superfamily. Arf family.,subcellular location:Membrane-associated with the Golgi complex and lysosomal structures.,subunit:Interacts with PSCD1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
