产品名称
CRTAP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10491
Human Swissprot No.
O75718
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75718/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56693
Mouse Swissprot No.
Q9CYD3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CYD3
免疫原
Synthesized peptide derived from human CRTAP AA range: 65-115
特异性
This antibody detects endogenous levels of CRTAP at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008],
组织表达
Found in articular chondrocytes. Expressed in a variety of tissues.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
disease:Defects in CRTAP are the cause of osteogenesis imperfecta type 2B (OI-2B) [MIM:610854]. OI-2B is an autosomal recessive form of perinatal lethal OI. This form is designated OI-2B to distinguish it from the autosomal dominant form OI-2A.,disease:Defects in CRTAP are the cause of osteogenesis imperfecta type 7 (OI-7) [MIM:610682]. OI is a connective tissue disorder characterized by bone fragility and low bone mass. OI-7 is an autosomal recessive form of OI.,similarity:Belongs to the CRTAP/No55 family.,tissue specificity:Found in articular chondrocytes. Expressed in a variety of tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
