产品名称
FYCO1 Rabbit Polyclonal Antibody
蛋白名称
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9BQS8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BQS8/entry
Mouse Swissprot No.
Q8VDC1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VDC1
免疫原
Synthesized peptide derived from part region of human protein
特异性
FYCO1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
FYVE and coiled-coil domain containing 1(FYCO1) Homo sapiens This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011],
组织表达
Expressed in heart and skeletal muscle.
细胞定位
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
功能
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 GOLD domain.,similarity:Contains 1 RUN domain.,tissue specificity:Expressed in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
