产品名称
FOLR2 Rabbit Polyclonal Antibody
蛋白名称
Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P14207
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P14207/entry
Mouse Swissprot No.
Q05685
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q05685
免疫原
Synthesized peptide derived from part region of human protein
特异性
FOLR2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor. Secreted .
功能
function:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.,PTM:Eight disulfide bonds are present.,PTM:N-glycosylated.,similarity:Belongs to the folate receptor family.,tissue specificity:Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
