产品名称
NMDARA2 Rabbit Polyclonal Antibody
别名
Glutamate [NMDA] receptor subunit epsilon-1 (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2903
Human Swissprot No.
Q12879
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12879/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14811
Mouse Swissprot No.
P35436
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P35436
Rat Gene Link
https://www.uniprot.org/uniprot/24409
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q00959
特异性
This antibody detects endogenous levels of NMDARA2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain,Cerebellum,Epithelium,Hippocampus,
细胞定位
Cell projection, dendritic spine . Cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. .
功能
function:NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4. Interacts with HIP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
