产品名称
AGO3 Rabbit Polyclonal Antibody
蛋白名称
Protein argonaute-3 (Argonaute3) (hAgo3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9H9G7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H9G7/entry
Mouse Swissprot No.
Q8CJF9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CJF9
免疫原
Synthesized peptide derived from part region of human protein
特异性
AGO3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
功能
function:Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.,similarity:Belongs to the argonaute family. Ago subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subunit:Interacts with EIF4B, IMP8, PRMT5 and TNRC6B.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
