产品名称
PLEKHG5 Rabbit Polyclonal Antibody
别名
Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57449
Human Swissprot No.
O94827
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O94827/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/269608
Mouse Swissprot No.
Q66T02
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q66T02
Rat Gene Link
https://www.uniprot.org/uniprot/310999
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6RFZ7
特异性
This antibody detects endogenous levels of PLEKHG5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines.
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Cell junction . Cell projection, lamellipodium . Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells. .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
