产品名称
DHB8 Rabbit Polyclonal Antibody
基因名称
HSD17B8 FABGL HKE6 RING2
蛋白名称
Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.63)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92506
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92506/entry
Mouse Swissprot No.
P50171
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P50171
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6MGB5
免疫原
Synthesized peptide derived from part region of human protein
特异性
DHB8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
hydroxysteroid 17-beta dehydrogenase 8(HSD17B8) Homo sapiens In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed, particularly abundant in prostate, placenta and kidney (PubMed:17978863). Expressed at protein level in various tissues like brain, cerebellum, heart, lung, kidney, ovary, testis, adrenals and prostate (PubMed:30508570).
细胞定位
Mitochondrion matrix .
信号通路
Steroid hormone biosynthesis;Androgen and estrogen metabolism;
功能
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,catalytic activity:Testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH.,function:Uses estradiol as its preferred substrate.,pathway:Steroid biosynthesis; estrogen biosynthesis.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,tissue specificity:High expression in the liver and pancreas, lower in the skeletal muscle and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
