产品名称
HP1-β Rabbit Polyclonal Antibody
别名
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10951
Human Swissprot No.
P83916
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P83916/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12412
Mouse Swissprot No.
P83917
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P83917
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of HP1-β at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in all adult and embryonic tissues.
细胞定位
Nucleus . Unassociated with chromosomes during mitosis.
功能
function:Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.,online information:Heterochromatin protein 1 entry,PTM:Not phosphorylated.,similarity:Contains 2 chromo domains.,subcellular location:Unassociated with chromosomes during mitosis.,subunit:Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6.,tissue specificity:In all adult and embryonic tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
