产品名称
DHB2 Rabbit Polyclonal Antibody
蛋白名称
Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.63)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P37059
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P37059/entry
Mouse Swissprot No.
P51658
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51658
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62730
免疫原
Synthesized peptide derived from part region of human protein
特异性
DHB2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,catalytic activity:Testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH.,function:Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,
组织表达
Expressed in placenta.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
信号通路
Steroid hormone biosynthesis;Androgen and estrogen metabolism;
功能
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,catalytic activity:Testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH.,function:Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
