产品名称
HIPK1/2/3 Rabbit Polyclonal Antibody
别名
Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Nuclear body-associated kinase 2)
基因名称
HIPK1 KIAA0630 MYAK NBAK2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=204851
Human Swissprot No.
Q86Z02
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86Z02/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/15257
Mouse Swissprot No.
O88904
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88904
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A4L9P5
特异性
This antibody detects endogenous levels of HIPK1/2/3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. Expressed in both androgen-dependent and androgen-independent prostate cancer cells (PubMed:28289210).
细胞定位
Nucleus . Cytoplasm . Nucleus speckle . Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.,PTM:Autophosphorylated. Phosphorylated and activated by JNK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly nuclear.,subunit:Interacts with Nkx1-2 and Nkx2-5 (By similarity). Interacts with DAXX and TP53.,tissue specificity:Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
