产品名称
DYRK2/4 Rabbit Polyclonal Antibody
别名
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8445
Human Swissprot No.
Q92630
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92630/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/69181
Mouse Swissprot No.
Q5U4C9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U4C9
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/0
特异性
This antibody detects endogenous levels of DYRK2/4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Testis, after the onset of spermatogenesis.
细胞定位
Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,cofactor:Manganese.,enzyme regulation:Autophosphorylates on tyrosine residues.,function:Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.,PTM:Phosphorylated on serine/threonine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Translocates into the nucleus following DNA damage.,tissue specificity:Testis, after the onset of spermatogenesis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
