产品名称
STAT5A/B Rabbit Polyclonal Antibody
别名
Signal transducer and activator of transcription 5A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6776
Human Swissprot No.
P42229
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P42229/entry
Rat Gene Link
https://www.uniprot.org/uniprot/24918
特异性
This antibody detects endogenous levels of STAT5A/B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain,Cervix,Epithelium,Lung,Placenta,Synovial memb
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.
功能
function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,PTM:Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
