产品名称
DHB12 Rabbit Polyclonal Antibody
蛋白名称
Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (EC 1.3.1.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q53GQ0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q53GQ0/entry
Mouse Swissprot No.
O70503
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70503
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6P7R8
免疫原
Synthesized peptide derived from part region of human protein
特异性
DHB12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011],
组织表达
Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
信号通路
Steroid hormone biosynthesis;Androgen and estrogen metabolism;Biosynthesis of unsaturated fatty acids;
功能
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,domain:The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.,function:Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.,pathway:Lipid metabolism; fatty acid biosynthesis.,pathway:Steroid biosynthesis; estrogen biosynthesis.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.,tissue specificity:Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
