产品名称
p38-γ/δ Rabbit Polyclonal Antibody
别名
Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6300
Human Swissprot No.
P53778
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P53778/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/29857
Mouse Swissprot No.
O08911
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O08911
Rat Gene Link
https://www.uniprot.org/uniprot/60352
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63538
特异性
This antibody detects endogenous levels of p38-γ/δ at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in skeletal muscle and heart.
细胞定位
Cytoplasm. Nucleus. Mitochondrion. Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 2 magnesium ions.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by phosphorylation on threonine and tyrosine.,function:Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.,PTM:Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Mitochondrial when associated with SH3BP5.,subunit:Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5.,tissue specificity:Highly expressed in skeletal muscle and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
