产品名称
OPTN Rabbit Polyclonal Antibody
别名
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
基因名称
OPTN FIP2 GLC1E HIP7 HYPL NRP
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10133
Human Swissprot No.
Q96CV9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96CV9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/71648
Mouse Swissprot No.
Q8K3K8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3K8
Rat Gene Link
https://www.uniprot.org/uniprot/246294
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R5M4
特异性
This antibody detects endogenous levels of OPTN at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
细胞定位
Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
