产品名称
DHB1 Rabbit Polyclonal Antibody
基因名称
HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17
蛋白名称
Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Placental 17-beta-hydroxysteroid dehydrogenase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P14061
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P14061/entry
Mouse Swissprot No.
P51656
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51656
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P51657
免疫原
Synthesized peptide derived from part region of human protein
特异性
DHB1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
hydroxysteroid 17-beta dehydrogenase 1(HSD17B1) Homo sapiens This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has
组织表达
Brain,Placenta,Skin,
信号通路
Steroid hormone biosynthesis;Androgen and estrogen metabolism;
功能
catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,function:Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.,online information:The Singapore human mutation and polymorphism database,pathway:Steroid biosynthesis; estrogen biosynthesis.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
