BD-PN0704

ERD21 Rabbit Polyclonal Antibody

常规抗体

KDELR1 ERD2.1

ER lumen protein retaining receptor 1 (KDEL endoplasmic reticulum protein retention receptor 1) (KDEL receptor 1) (Putative MAPK-activating protein PM23)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

10945

P24390

https://www.uniprot.org/uniprotkb/P24390/entry

Q99JH8

http://www.uniprot.org/uniprot/Q99JH8

Q569A6

http://www.uniprot.org/uniprot/O54941Q569A6

Synthesized peptide derived from part region of human protein

ERD21 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

23kD

-20°C/1 year

Polyclonal, Rabbit,IgG

KDEL endoplasmic reticulum protein retention receptor 1(KDELR1) Homo sapiens Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to t

Lung fibroblast,Muscle,Placenta,Skin,

Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPI-coated vesicle membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. .

Vibrio cholerae infection;

function:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi.,function:Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.,similarity:Belongs to the ERD2 family.,subunit:Interacts with ARFGAP1.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.